Serum osteocalcin and urinary free deoxypyridinoline as potential risk factors in predicting the prevalence of bone trauma among the post-menopausal Chinese women

Anqing Jiang; Yijie Liu; Xuefeng Li; Jie Chen; Heng Wang; Huilin Yang; Weimin Jiang

Anqing Jiang Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China http://orcid.org/0000-0002-2938-0620
Yijie Liu Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China http://orcid.org/0000-0001-9976-856X
Xuefeng Li Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China http://orcid.org/0000-0002-7291-5096
Jie Chen Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China http://orcid.org/0000-0002-6775-7492
Heng Wang Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China http://orcid.org/0000-0002-9390-1689
Huilin Yang Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. http://orcid.org/0000-0003-4637-5177
Weimin Jiang Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China http://orcid.org/0000-0001-8650-9403

Keywords: Bone trauma, Chinese woman, Deoxypyridinoline, Post-menopausal, Prevalence, Serum osteocalcin, Urine, Clinical trial

DOI: 10.3329/bjp.v13i3.36834

Abstract

This study was designed to understand whether the post-menopausal Chinese women (n=175) receiving tablet containing vitamin D (500 IU) and calcium (500 mg) had lower incidence of bone fracture compared to the post-menopausal Chinese women ((n=175) receiving a diet rich in calcium, vitamin D, and protein (milk, cheese, and yogurt, soybeans, spinach, fish including fatty fish, cheese, egg). This study assessed whether the levels of serum osteocalcin and urinary free deoxypyridinoline could be used as predictors of early bone trauma during post-menopausal period. After randomization, subjects were followed-up for up to 3 years to capture required data. The results suggested that therapeutic intervention (vitamin D and calcium) does not predict bone fracture among the post-menopausal Chinese women. However, correlation analysis revealed that the decreased level of serum osteocalcin and urinary free deoxypyridinoline were associated with higher incidence of fracture. The results suggest that the low level of serum osteocalcin and urinary free deoxypyridinoline cause increase susceptibility of fracture among the post-menopausal Chinese women.

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Serum osteocalcin and urinary free deoxypyridinoline as potential risk factors in predicting the prevalence of bone trauma among the post-menopausal Chinese women

Abstract

References

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