Anti-cancer agents from medicinal plants

  • Mohammad Shoeb Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh.
Keywords: Anti-cancer, Cytotoxicity, Medicinal plant, Natural product, Taxol, Mini-Review
DOI: 10.3329/bjp.v1i2.486

Abstract

Cancer is a major public health burden in both developed and developing countries. Plant derived agents are being used for the treatment of cancer. Several anticancer agents including taxol, vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, and etoposide derived from epipodophyllotoxin are in clinical use all over the world. A number of promising agents such as flavopiridol, roscovitine, combretastatin A-4, betulinic acid and silvestrol are in clinical or preclinical development.

References

Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci. 2005; 78: 431-41.

Bertino JR. Irinotecan for colorectal cancer. Semin Oncol. 1997; 24: S18-23.

Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod. 2004; 67: 2141-53.

Cichewicz RH, Kouzi SA. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev. 2004; 24: 90-114.

Cox PA. Ethnopharmacology and the search for new drugs. In: Bioactive compounds from plants. Ciba Foundation Symposium 154. Chichester, England, John Wiley and Sons, 1990, pp 40-55.

Christian MC, Pluda JM, Ho PT, Arbuck SG, Murgo AJ, Sausville EA. Promising new agents under development by division of cancer treatment, diagnosis, and centers of the National Cancer Institute. Semin Oncol. 1997; 24: 219-40.

Cragg GM, Newman DJ, Snader KM. Natural products in drug discovery and development. J Nat Prod. 1997; 60: 52-60.

Cragg GM, Newman DJ. Plants as source of anti-cancer agents. J Ethnopharmacol. 2005; 100: 72-79.

Creemers GJ, Bolis G, Gore M, Scarfone G, Lacave AJ, Guastalla JP, Despax R, Favalli G, Kreinberg R, VanBelle S, Hudson I, Verweij J, Ten Bokkel Huinink WW. Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: Results of a large European phase II study. J Clin Oncol. 1996; 14: 3056-61.

Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z. Medicinal plants in therapy. Bull World Health Organ. 1985; 63: 965-81.

Hartwell JL. Plants used against cancer: A survey. Lawrence, MA. Quarterman Publications, 1982, pp 438-39.

Harvey AL. Medicines from nature: Are natural products still relevant to drug discovery. Trends Pharmacol Sci. 1999; 20: 196-98.

Hoyer DL, Kung HC, Smith BL. Deaths: Preliminary data for 2003. Natl Vital Stat Rep. 2005; 53: 1-48.

Hwang BY, Su BN, Chai H, Mi Q, Kardono LB, Afriastini JJ, Riswan S, Santarsiero B D, Mesecar AD, Wild R, Fairchild CR, Vite GD, Rose WC, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. Silvestrol and episilvestrol, potential anti-cancer rocaglate derivatives from Aglaila silvestris. J Org Chem. 2004; 69: 3350-58 (ibid. 69 (18), 6156).

Itokawa H, Wang X, Lee KH. Homoharringtonine and related compounds. In: Cragg GM, Kingston, DGI, Newman D, (eds). Anti-cancer agents from natural products. Boca Raton, Florida, Brunner-Routledge Psychology Press, Taylor & Francis Group, 2005, pp 47-70.

Jaspars M, Lawton LA. Cyanobacteria as a novel source of pharmaceuticals. Curr Opin Drug Discov Devel. 1998; 1: 77-84.

Kantarjian HM, O’Brien S, Anderlini P, Talpaz M. Treatment of chronic myelogenous leukemia: Current status and investigational options. Blood 1996; 87: 3069-81.

Kapoor LD. CRC Handbook of ayurvedic medicinal plants. Boca Raton, Florida, CRC Press, 1990, pp 416-17.

Kelland LR. Flavopiridol, the first cyclic-dependent kinase inhibitor to enter the clinic: Current status. Expert Opin Investig Drugs. 2000; 9: 2903-11.

Meijer L, Raymond E. Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. Acc Chem Res. 2003; 36: 417-25.

Mi Q, Cui B, Silva GL, Lantvit D, Lim E, Chai H, You M, Hollingshead MG, Mayo JG, Kinghorn AD, Pezzuto JM. Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype. Cancer Res. 2001; 61: 430-37.

Mi Q, Cui B, Lantvit D, Reyes-Lim E, Chai H, Pezzuto JM, Kinghorn AD, Swanson SM. Pervilleine F, a new tropane alkaloid aromatic ester that reverses the multidrug-resistance phenotype. Anti-cancer Res. 2003; 23: 3607-15.

Nahar N, Das RN, Shoeb M, Marma MS, Aziz MA, Mosihuzzaman M. Four triterpenoids from the bark of Zizyphus rugosa and Z. oenoplia. J Bangladesh Aca Sci. 1997; 21: 151-56.

Oberlines NH, Kroll DJ. Camptothecins and taxol: Historic achievement in natural products research. J Nat Prod. 2004; 67: 129-35.

Ohsumi K, Nakagawa R, Fukuda Y, Hatanaka T, Morinaga Y, Nihei Y, Ohishi K, Suga Y, Akiyama Y, Tsuji T. New combretastatin analogues effective against murine solid tumors: Design and structure-activity relationship. J Med Chem. 1998; 41: 3022-32.

Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005; 55: 74-108.

Pettit GR, Singh SB, Niven ML, Hamel E, Schmidt JM. Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. J Nat Prod. 1987; 50: 119-31.

Pettit GR, Singh SB, Boyd MR, Hamel E, Pettit R, Schmidt JM, Hogan F. Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5 and A-6. J Med Chem. 1995; 38: 1666-72.

Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH, Kinghorn AD, Brown DM, Wani MC, Wall ME, Hieken TJ, Das Gupta TK, Pezzuto JM. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med. 1995; 1: 1046-51.

Potmeisel M, Pinedo H. Camptothecins: New anti-cancer agents. Boca Raton, Florida, CRC Press, 1995, pp 149-50.

Powell RG, Weisleder D, Smith Jr CR, Rohwedder WK. Structures of harringtonine, isoharringtonine, and homoharringtonine. Tetrahedron Lett. 1970; 11: 815-18.

Rowinsky EK, Onetto N, Canetta RM, Arbuck SG. Taxol-the 1st of the texanes, an important new class of anti-tumor agents. Semin Oncol. 1992; 19: 646-62.

Samuelsson G. Drugs of natural origin: A textbook of pharmacognosy. 4th ed., Stockholm, Swedish Pharmaceutical Press, 1999.

Shoeb M. Cytotoxic compounds from the Genus Centaurea. PhD Thesis. Aberdeen, UK, The Robert Gordon University, 2005.

Shoeb M, Celik S, Jaspars M, Kumarasamy Y, MacManus SM, Nahar L, Thoo-Lin PK, Sarker SD. Isolation, structure elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii. Tetrahedron. 2005; 61: 9001-06.

Shoeb M, MacManus SM, Jaspars M, Trevidu J, Nahar L, Thoo-Lin PK, Sarker SD. Montamine, a unique dimeric indole alkaloid, from the seeds of Centaurea montana (Asteraceae), and its in vitro cytotoxic activity against the CaCo2 colon cancer cells. Tetrahedron 2006; 62: 11172-77.

Silva GL, Cui B, Chavez D, You M, Chai HB, Rasoanaive P, Lynn SM, O'Neill MJ, Lewis JA, Besterman JM, Monks A, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Modulation of the multidrug-resistance phenotype by new tropane alkaloids aromatic esters from Erythroxylum pervillei. J Nat Prod. 2001; 64: 1514-20.

Stahblin H. Activity of a new glycosidic lignan derivative (VP 16-213) related to podophyllotoxin in experimental tumors. Eur J Cancer. 1973; 9: 215-21.

Wall ME, Wani MC. Camptothecin and taxol: Ffrom discovery to clinic. J Ethnopharmacol. 1996; 51: 239-54.

Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant anti-tumor agents. VI. The isolation and structure of taxol, a novel anti-leukemic and anti-tumor agent from Taxus brevifolia. J Am Chem Soc. 1971; 93: 2325-27.

Published
2008-01-03

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Section
Mini Review
Financial Support
Self-funded
Conflict of Interest
The author declares no conflict of interest