Effect of Garcinia indica against brain ischemic reperfusion in rat model

Abstract

The term, ischemia, refers to a condition which is characterized by enormous reduction of glucose and oxygen. In cerebral ischemia, the cerebral blood flow become insufficient in order to pursue cerebral meta-bolic activities (Ahmed at al., 2018). Both, the inflammation and oxidative stress have a promising role in cerebral infarction associated with ischemic reperfusion insult. The reperfusion insult results in an initiation of a number of events including stress oxida-tive, devastation of blood brain barrier, leukocytes intrusion, inflammation, apoptosis and nitric oxide discharge, etc. In this context, potential antioxidant and anti-inflammatory intermediaries might play their role to lessen the effects produced as a result of ischemic reperfusion insult. Due to lack of active treatment of ischemic reperfusion associated cerebral ischemia, researchers interest in developing some effective therapy from medicinal plants is obvious (Kalogeris et al., 2012). In order to get to know about the mechanism of cell demise and neuroprotection, a classical rat’s model is widely used. In this model, the forebrain slices of the animal are bare to oxygen and glucose deficiency and reperfusion (Ca´rdenas et al., 2000). The advantages of this model are time tested as cell composition is preserved.