Antimicrobial metabolites from Streptomyces sp. strain PDH23 derived from marine sponge Rhabdastrella globostellata
Abstract
Sponge-associated bacterial community has shown great potential as a source of biologically active constituents. The marine sponge Rhabdastrella globostellata has been known to display potent anticancer effects (Hirashima et al. 2010; Li et al., 2010, Aoki et al., 2007). Pandey et al. (2014) revealed that 18 of 127 microorganisms isolated from R. globostellata exhibited acetylcholinesterase inhibitory activity. However, the antimicrobial activity of R. globostellata associated bacteria has not been reported so far. In our search for antibacterial agents from marine organisms, the strain of Streptomyces sp. PDH23 isolated from R. globostellata, which was collected at depth of 10 m in Da Nang sea, Vietnam, was found to exhibit remarkable antimicrobial activity against Bacillus cereus (ATCC14579) and Candida albicans (ATCC1023) (see supplemental data).
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