Medicinal plants with wound healing potential
Abstract
Wound occurs due to disruption of soft tissues that results from injury. Recently many medicinal plants have been demonstrated for wound healing potential through in vivo and in vitro preclinical models and their mechanisms of wound healing has also been reported. Medicinal plants have been reported to show wound healing potential via angiogenesis, activation of NF-κB, favoring pro-inflammatory cytokines, increased expression of inducible nitric oxide synthase (iNOS) and alpha 1 type 1 collagen, and antioxidant activity. Thus, in this review, an attempt was made to give an insight into the recently reported medicinal plants with wound healing mechanisms which could be beneficial in therapeutic practice and development of new wound healing drugs for human use.
References
Hegazi GAEM. In vitro studies on Delonix elata L.: An endangered medicinal plant. World Appl Sci J. 2011; 14: 679–86.
Ahangarpour A, Mohammadian M, Dianat M. Antidiabetic effect of hydroalcholic Urtica dioica leaf extract in male rats with fructose-induced insulin resistance. Iran J Med Sci. 2012; 37: 181-86.
Ali M, Ansari SH. Hair care and herbal drugs. Indian J Nat Prod. 1997; 13: 3-5.
Artizzu N, Bonsignore L, Cottiglia F, Loy G. Studies on the diuretic and antimicrobial activity of Cynodon dactylon essential oil. Fitoterapia 1996; 67: 174-76.
Ashkani-Esfahani S, Imanieh M, Khoshneviszadeh M, Meshksar A, Noorafshan A, Geramizadeh B, Ebrahimi S, Handjani F, Tanideh N. The healing effect of Arnebia euchroma in second degree burn wounds in rat as an animal model. Iran Red Crescent Med J. 2012; 14: 70-74.
Atiba A, Ueno H, Uzuka Y. The effect of Aloe vera oral administration on cutaneous wound healing in type 2 diabetic rats. J Vet Med Sci. 2011; 73: 583-89.
Babaei E, Mohammad HA, Mehdikhani F, Milad M, Emad G, RHP. The healing effects of herbal preparations from Sambucus ebulus and Urtica dioica in full-thickness wound models. Asian Pac J Trop Biomed. 2017; 7: 421-27.
Bacchi EM, Sertie JAA. Antiulcer action of Styrax camporum and Caesalpinia ferrea in rats. Planta Med. 1994; 60: 118-20.
Balbach A. As Plantas que Curam, Três Press. São Paulo, 1972.
Basch E, Bent S, Foppa I, Haskmi S, Kroll D, Mele M, Szapary P, Ulbricht C, Vora M, Yong S. Marigold (Calendula officinalis L.): An evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother. 2006; 6: 135-59.
Bhavamishra. Bhavaprakasa Nighantu (Indian Materia Medica). In: Chunekar, K.C., (Ed.), Chaukhambha Bharati Academy, Varanasi, 2010, pp 686-87.
Behm B, Babilas P, Landthaler M, Schreml S. Cytokines, chemokines and growth factors in wound healing. J Eur Acad Dermatol Venereol. 2012; 26: 812-20.
Bhaskar A, Nithya V. Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats. Indian J Pharmacol. 2012; 44: 694-98.
Biswas TK, Pandit S, Chakrabarti S, Banerjee S, Poyra N, Seal T. Evaluation of Cynodon dactylon for wound healing activity. J Ethnopharmacol. 2017; 197: 128-37.
Borchers AT, Keen CL, Stern JS, Gershwin ME. Inflammation and Native American medicine: The role of botanicals. Am J Clin Nutr. 2000; 72: 339-47.
Braga R. Plantas do Nordeste, Especialmente do Ceará. Três Press. São Paulo, 1976.
Brusotti G, Andreola F, Sferrazza G, Grisoli P, Merelli A, Cuna FSRD, Calleri E, Nicotera G, Pierimarchi P, Serafino A. In vitro evaluation of the wound healing activity of Drypetes klainei stem bark extracts. J Ethnopharmacol. 2015; 175: 412-21.
Brusotti G, Tosi S, Tava A, Picco AM, Grisoli P, Cesari I, Caccialanza G. Antimicrobial and phytochemical properties of stem bark extracts from Piptadeniastrum africanum (Hook f.) Brenan. Ind Crops Prod. 2013; 43: 612-16.
Carvalho JCT, Teixeira JRM, Souza PJC, Bastos JK, Santos-Filho D, Sarti SJ. Preliminary studies of analgesic and anti-inflammatory properties of Caesalpinia ferrea crude extract. J Ethnopharmacol. 1996; 53: 175-78.
Cesari I, Grisoli P, Paolillo M, Milanese C, Massolini G, Brusotti G. Isolation and characterization of the alkaloid Nitidine responsible for the traditional use of Phyllanthus muellerianus (Kuntze) Excell stem bark against bacterial infections. J Pharm Biomed Anal. 2015; 105: 115-20.
Chan EWC, Lim YY, Wong LF, Lianto FS, Wong SK, Lim KK, et al. Antioxidant and tyrosinase inhibition properties of leaves and rhizomes of ginger species. Food Chem. 2008; 109: 477-83.
Chang YC, Huang KX, Huang AC, Ho YC, Wang CJ. Hibiscus anthocyanins-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis. Food Chem Toxicol. 2006; 44: 1015-23.
Chrubasik JE, Roufogalis BD, Wagner H, Chrubasik SA. A comprehensive review on nettle effect and efficacy profiles, part I: Herba urticae. Phytomedicine 2007; 14: 423-35.
Dande P, Khan A. Evaluation of wound healing potential of Cynodon dactylon. Asian J Pharm Clin Res. 2012; 5: 161-64.
Daburkar M, Lohar V, Rathore AS, Bhutada R, Tangadpaliwar S. An in vivo and in vitro investigation of the effect of Aloe vera gel ethanolic extract using animal model with diabetic foot ulcer. J Pharm Bioallied Sci. 2014; 6: 205-12.
Dewanjee S, Dua TK, Sahu R. Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: A wild edible plant. Food Chem Toxicol. 2013; 59: 514-20.
Dinda M, Dasgupta U, Singh N, Bhattacharyya D, Karmakar P. PI3K-Mediated proliferation of fibroblasts by Calendula officinalis tincture: Implication in wound healing. Phytother Res. 2015; 29: 607-16.
D'Souza KM, Malhotra R, Philip JL, Staron ML, Theccanat T, Jeevanandam V, Akhter SA. G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts. J Biol Chem. 2011; 286: 15507-16.
Eghdampour F, Jahdie F, Kheyrkhah M, Taghizadeh M, Naghizadeh S, Hagani H. The Impact of Aloe vera and Calendula on Perineal Healing after Episiotomy in Primiparous Women: A Randomized Clinical Trial. J Caring Sci. 2013; 2: 279-86.
Ebrahimzadeh MA, Mahmoudi M, Karami M, Saeedi S, Ahmadi AH, Salimi E. Separation of active and toxic portions in Sambucus ebulus. Pakistan J Biol Sci. 2007; 10: 4171-73.
Ebrahimzadeh MA, Rafati MR, Damchi M, Golpur M, Fathiazad F. Treatment of Paederus dermatitis with Sambucus ebulus. Iran J Pharm Res. 2014; 13: 1065-71.
Ekor M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2013; 4: 1-10.
ESCOP Monographs: The scientific foundation for herbal medicinal products. United Kingdom, 2003.
Frank S, Madlener M, Pfeilschifter J, Werner S. Induction of inducible nitric oxide synthase and its corresponding tetrahydrobiopterin-cofactor-synthesizing enzyme GTP-cyclohydrolase I during cutaneous wound repair. J Invest Dermatol. 1998; 111: 1058-64.
Fujita K, Hidaka M, Takamura N, Yamasaki K, Iwakiri T, Okumura M, Kodama H, Yamaguchi M, Ikenoue T, Arimori K. Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans. Biol Pharm Bull. 2003; 26: 1371-73.
Ghabaee DNZ, Ebrahimzadeh MA, Akbari J and Amiri FT. Wound healing activity of Sambucus ebulus. Int J Pharm Sci Res. 2017; 8: 132-35.
Guo S, DiPietro LA. Factors Affecting Wound Healing. J Dent Res. 2010; 89: 219-29.
Gruenwald J, Brendler T, Jaenicke C. Physician’s desk reference for herbal medicines (PDR). USA, Medical Economics Company, 2000.
Hajhashemi V, Ghannadi A, Heidari AH. Anti-inflammatory and wound healing activities of Aloe littoralis in rats. Res Pharm Sci. 2012; 7: 73-78.
Herrera-Arellano A, Flores-Romero S, Chávez-Soto MA, Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: A controlled and randomized clinical trial. Phytomedicine 2004; 11: 375-82.
Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsale A, Suthisisang C. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol. 2006; 103: 252-60.
Hosoi S, Shimizu E, Usami N, Yamamoto I, Arimori K, Okumura M, Hidaka M, Yamada M, Sakushima A. Isolation of cytochrome P450 3A (CYP3A) inhibitors from Hyuganatsu, Citrus tamurana. Hort J Nat Med. 2006; 60: 240-42.
Hou DX, Tong X, Terahara N, Luo D, Fujii M. Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys. 2005; 440: 101-09.
Jadhao KD, Wadekar MP. Evaluation and study of minerals from Leea macrophylla Roxb (Leeaceae). Asian J Chem. 2010; 22: 2480-82.
Jaradat NA, Al-Ramahi R, Zaid AN. Ethnopharmacological survey of herbal remedies used for treatment of various types of cancer and their methods of preparations in the West Bank-Palestine. BMC Complement Altern Med. 2016; 16: 93.
Joshi A, Joshi VK, Pandey D, Hemalatha S. Systematic investigation of ethanolic extract from Leea macrophylla: Implications in wound healing. J Ethnopharmacol. 2016; 191: 95-106.
Kirtikar KK, Basu BD. Indian medicinal plants. 2nd Ed. Lalit Mohan Publication, India, 1980.
Kirtikar KR, Basu BD. Indian medicinal plants, M/s Bishen Singh Mahendra Pal Singh, Dehra Dun, 1975, pp 617.
Kim YM, Namkoong S, Yun YG, Hong HD, Lee YC, Ha KS, Lee H, Kwon HJ, Kwon YG, Kim YM. Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells. Biol Pharm Bull. 2007; 30: 1674-79.
Kittana N, Abu-Rass H, Sabra R, Lama M, Hanany H, Jaradat N, Hussein F, Zaid AN. Topical aqueous extract of Ephedra alata can improve wound healing in an animal model. Chin J Traumatol. 2017; 20: 108-13.
Klass BR, Grobbelaar AO, Rolfe KJ. Transforming growth factor beta 1 signalling, wound healing and epiair: A multifunctional cytokine with clinical implications for wound repair, a delicate balance. Postgrad Med J. 2009; 85: 9-14.
Krishnappa P, Venkatarangaiah K, Venkatesh, Rajanna SKS, Balan RK. Wound healing activity of Delonix elata stem bark extract and its isolated constituent quercetin-3-rhamno-pyranosyl-(1-6) glucopyranoside in rats. J Pharm Anal. 2016; 6: 389-95.
Kumar A, Kashyap P. Wound healing activity of Cynodon dactylon (L.) Pers. in albino Wistar rats. Int J phytopharm. 2013; 3: 63–67.
Kumar B, Vinaykumar M, Govindarajan R, Pushpangadan P. Ethanopharmacological approaches to wound healing exploring medicinal plants of India. J Ethanopharmacol. 2007; 114: 103–13.
Kupeli Akkol E, Demirel MA, Bahadir Acikara O, Süntar I, Ergene B, Ilhan M, Ozbilgin S, Saltan G, Keles H, Tekin M. Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model. Arch Gynecol Obstet. 2015; 292: 619-28.
Kurup PN, Ramdas VN, Joshi P. Handbook of medicinal plants. New Delhi, Oxford and IBH Publishing Co. Pvt. Ltd, 1979, pp 86-87.
Lazarus GS, Cooper DM, Knighton DR, Margolis DJ, Pecoraro RE, Rodeheave G, Robson MC. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol. 1994; 130: 489-93.
Leach MJ. Calendula officinalis and wound healing: A systematic review. Wounds 2008; 20: 236-43.
Li J, Chen J, Kirsener R. Pathophysiology of acute Wound healing. Clin Dermatol. 2007; 25: 9-18.
Madhyastha HM, Masatoshi Y, Hiroshi S, Tsuyomu I, Masugi M. Revealing the mechanism of in vitro wound healing properties of Citrus tamurana extract. BioMed Res Int. 2013; 2013: 1-8.
Makau JN, Watanabe K, Kobayashi N. Anti-influenza activity of Alchemilla mollis extract: Possible virucidal activity against influenza virus particles. Drug Discov Ther. 2013; 7: 189-95.
Mangathayaru K, Umadevi M, Reddy CU. Evaluation of the immunomodulatory and DNA protective activities of the shoots of Cynodon dactylon. J Ethnopharmacol. 2009; 123: 181–84.
Mikhal'chik EV, Anurov MV, Titkova SM. Activity of antioxidant enzymes in the skin during surgical wounds. Bulletin Exp Biol Med. 2006; 142: 667-69.
Mirmalek S, Parsa T, Parsa Y, Yadollah-Damavandi S, Salimi-Tabatabaee S, Jangholi E, Hosseini S, Ashkani-Esfahani S, Abooghadareh H, Haghighifard E. The wound healing effect of Iris forentina on full thickness excisional skin wounds: A histomorphometrical study. Bangladesh J Pharmacol. 2016; 11: 86-90.
Mohamed EAK. Antidiabetic, antihypercholestermic and antioxidative effect of Aloe vera gel extract in alloxan-induced diabetic rats. Aust J Basic Appl Sci. 2011; 5: 1321-27.
Mohd AK, Saxena A, Fatima FT, Sharma G, Goud V, Husain A. Study of wound healing activity of Delonix regia flowers in experimental animal models. Am J PharmTech Res. 2012; 2: 380-90.
Mondal S, Ghosh G, Sagar N, Ganapaty S. Evaluation of Antioxidant, Toxicological and wound healing properties of Hibiscus rosa-sinensis L. (Malvaceae) ethanolic leaves extract on different experimental animal models. Indian J Pharm Edu Res. 2016; 50: 620-37.
Mueen Ahmed KK, Parsuraman S. Urtica dioica L., (Urticaceae): A stinging nettle. Sys Rev Pharm. 2014; 5: 6-8.
Muley B, Khadabadi S, Banarase N. Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): A review. Trop J Pharm Res. 2009; 8: 455-65.
Ngueyem TA, Brusotti G, Marrubini G, Grisoli P, Dacarro C, Vidari G, Finzi PV, Caccialanza G. Validation of use of a traditional remedy from Bridelia grandis (Pierre ex Hutch) stem bark against oral Streptococci. J Ethnopharmacol. 2008; 120: 13-16.
Najafi M, Nazemiyeh H, Garjani A, Ghavimi H, Gharekhani A. Cardioprotective effects of Cynodon dactylon against ischemia/reperfusion-induced arrhythmias. J Mol Cell Cardiol. 2007; 42: S12.
Nakamura ES, Kurosaki F, Arisawa M, Mukainaka T, Takayasu J, Okuda M, Tokuda H, Nishino H, Pastore F. Cancer chemopreventive effects of a Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis. J Ethnopharmacol. 2002; 81: 135-37.
Natarajan B, Paulsen BS. An ethnopharmacological study from Thane District, Maharashtra, India: Traditional knowledge compared with modern biological science. Pharm Biol. 2000; 38: 139-51.
Natho G, Mandaville JP. Flora of Eastern Saudi Arabia. Feddes Repertor. 1991; 102: 444.
Nayak BS, Raju SS, Orette FA, Rao AVC. Effects of Hibiscus rosa sinensis L (Malvaceae) on wound healing activity: A preclinical study in a Sprague Dawley rat. Int J Low Extrem Wounds. 2007; 6: 76-81.
Nicolaus C, Junghanns S, Hartmann A, Murillo R, Ganzera M, Merfort I. In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts. J Ethnopharmacol. 2017; 196: 94-103.
Nizami AN, Rahman MA, Ahmed NU, Islam MS. Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol–induced urolithiasis model of rats. Asian Pac J Trop Med. 2012; 5: 533-38.
Oliveira AF, Batista JS, Paiva ES, Silva AE, Farias YJMD, Damasceno CAR, Brito PD, Queiroz SAC, Rodrigues CMF, Freitas CIA. Evaluation of the Brazilian ironwood (Caesalpinia ferrea Mart. ex Tul. var. ferrea) healing activity on cutaneous lesions of goats. Rev Bras Plantas Med. 2010; 12: 302-10.
Oryan A, Naeini AT, Nikahval B, Gorjian E. Effect of aqueous extract of Aloe vera on experimental cutaneous wound healing in rat. Veterinarski Arhiv. 2010; 80: 509-22.
Öz BE, Ilhan M, Özbilgin S, Akkol EK, Acıkara ÖB, Saltan G, Keleş H, Süntar I. Effects of Alchemilla mollis and Alchemilla persica on the wound healing process. Bangladesh J Pharmacol. 2016; 11: 577-84.
Oudhia P. Medicinal weeds in groundnut fields of Chhattisgarh (India). Int Arachis Newslett. 1999; 19: 62–64.
Pawar RS, Khan SI, Khan IA. Glycosides of 20-deoxy derivatives of jujubogenin and pseudojujubogenin from Bacopa monniera. Planta Medica. 2007; 73: 380–83.
Parente LML, Ruy de Souza LJ, Tresvenzol LMF, Vinaud MC, de Paula JR, Paulo NM. Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil. Evid Based Complement Alternat Med. 2012; 2012: 1-7.
Patil MB, Jalalpure SS, Prakash NS, Kokate CK. Antiulcer properties of alcoholic extract of Cynodon dactylon in rats. Acta Hortic. 2005; 480: 115-18.
Pereira LDP, Mario RLM, Brizeno LAC, Nogueira FC, Ferreira EGM, Pereira MG, Assreuy AM. Modulator effect of a polysaccharide-rich extract from Caesalpinia ferrea stem barks in rat cutaneous wound healing: Role of TNF-α, IL-1β, NO, TGF-β. J Ethnopharmacol. 2016; 187: 213-23.
Priya KS, Gnanamani A, Radhakrishnan N, Babu M, Healing potential of Datura alba on burn wounds in albino rats. J Ethnopharmacol. 2002; 83: 193-99.
Puvabanditsin P, Vongtongsri R. Efficacy of Aloe vera cream in prevention and treatment of sunburn and suntan. J Med Asso Thai. 2005; 88: S173.
Razika L, Thanina AC, Nadjiba CM, Narimen B, Mahdi DM, Karim A. Antioxidant and wound healing potential of saponins extracted from the leaves of Algerian Urtica dioica L. Pak J Pharm Sci. 2017; 30: 1023-29.
Reuter J, Jocher A, Stump J. Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. Skin pharmacol physiol. 2008; 21: 106-10.
Shabana MM, Mirhom YW, Genenah AA. Study into wild Egyptian plants of potential medicinal activity. Ninth communication: Hypoglycaemic activity of some selected plants in normal fasting and alloxanised rats. Arch Exp Veterinarmed. 1990; 44: 389-94.
Sampaio FC, Pereira MSV, Dias CS, Costa VCO, Conde NCO, Buzalaf MAR. In vitro antimicrobial activity of Caesalpinia ferrea Martius fruits against oral pathogens. J. Ethnopharmacol. 2009; 124: 289-94.
Sastry CST, Kavathekar YY. Plants for Reclamation of Wastelands. Publications and Information Directorate, New Delhi, India, 1990, pp 317-18.
Saroja M, Santhi R, Annapoorani S. Wound Healing Activity of Flavonoid fraction of Cynodon dactylon in swiss albino mice. Int Res J Pharm. 2012; 3: 230-31.
Sengupta R. Combined wound healing activity of Calendula officinalis and Basil leaves. J Pharmacog Phytochem. 2017; 6: 173-76.
Sethi N, Nath D, Singh RK. Teratological study of an indigenous antifertility medicine, Hibiscus rosa sinensis in rats. Arogya J Health Sci. 1986; 12: 86-88.
Shadhan RM, Bohari SPM. Effects of Hibiscus sabdariffa Linn. fruit extracts on α-glucosidase enzyme, glucose diffusion and wound healing activities. Asian Pac J Trop Biomed. 2017; 7: 466-72.
Shafeie N, Naini AT, Hossein KJ. Comparison of different concentrations of Calendula officinalis gel on cutaneous wound healing. Biomed Pharmacol J. 2015; 8: 979-92.
Shen HM, Chen C, Jiang JY, Zheng YL, Cai WF, Wang B, Ling Z, Tang L, Wang YH, Shi GG. The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds. J Ethnopharmacol. 2017; 198: 291-301.
Singh MP, Singh RH, Udupa KN. Antifertility activity of a benzene extract of Hibiscus rosa sinensis flowers on female albino rats. Planta Medica. 1982; 44: 171-74.
Singh SK, Rai PK, Jaiswal D, Rai DK, Sharma B, Watal G. Protective effect of Cynodon dactylon against STZ induced hepatic injury in rats. J Ecophysiol Occup Health. 2008a; 8: 195-99.
Singh SK, Rai PK, Jaiswal D, Watal G. Evidence-based critical evaluation of glycemic potential of Cynodon dactylon. Evid Based Complement Alternat Med. 2008b; 5: 415-20.
Soltanipoor MA. Introduction to the Flora, Life Form and Chorology of Hormoz Island Plants, S. Iran, Rostaniha 2006; 7: 19-32.
Song HS, Park TW, Sohn UD, Shin YK, Choi BC, Kim CJ, Sim SS. The effect of caffeic acid on wound healing in skin-incised mice. Korean J Physiol Pharmacol. 2008; 12: 343-47.
Stallmeyer B, Pfeilschifter J, Frank S. Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice. Diabetologia 2001; 44: 471.
Sunday AG, Ifeanyi OE, Ezeja MI. Wound healing potentials of leaf and bark extracts of Delonix regia. World J Pharm Pharm Sci. 2014; 3: 133-42.
Süntar IP, Akkol EK, Yalçin FN, Koca U, Keleş H, Yesilada E. Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside. J Ethnopharmacol. 2010; 129: 106-14.
Takzare N, Hosseini MJ, Hasanzadeh G, Mortazavi H, Takzare A, Habibi P. Influence of Aloe Vera gel on dermal wound healing process in rat. Toxicol Mech Methods. 2009; 19: 73-77.
Trendafilova A, Todorova M, Nikolova M, Gavrilova A, Vitkova A. Flavonoid constituents and free radical scavenging activity of Alchemilla mollis. Nat Prod Commun. 2011; 6: 1851-54.
Uncini Manganelli RE, Zaccaro L, Tomei PE. Antiviral activity in vitro of Urtica dioica L., Parietaria diffusa M. et K. and Sambucus nigra L. J Ethnopharmacol. 2005; 98: 323-27.
Vanhaesebroeck B. Charging the batteries to heal wounds through PI3K. Nat Chem Biol. 2006; 2: 453-55.
Vogl S, Picker P, Mihaly-Bison J, Fakhrudin N, Atanasov AG, Heiss EH, Wawrosch C, Reznicek G, Dirsch VM, Saukel J, Kopp B. Ethnopharmacological in vitro studies on Austria's folk medicine: An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs. J Ethnopharmacol. 2013; 149: 750-71.
Witte MB, Barbul A. Role of nitric oxide in wound repair. Am J Surg. 2002; 183: 406-12.
Wullaert A, Bonnet MC, Pasparakis M. NF-κB in the regulation of epithelial homeostasis and inflammation. Cell Res. 2011; 21: 146-58.
Yoshizaki H, Ohba Y, Parrini MC, Dulyaninova NG, Bresnick AR, Mochizuki N, Matsuda M. Cell type-specific regulation of RhoA activity during cytokinesis. J Biol Chem. 2004; 279: 44756-62.
Yagi A, Hegazy S, Kabbash A. Possible hypoglycemic effect of Aloe Vera L. high molecular weight fractions on type, 2009; 2: 209-15.
Yamaguchi M, Sameshima H, Ikenoue T, Tsuboi M, Hidaka M, Arimori K. Hyuganatsu orange (Citrus tamurana Hort. Ex Tanaka) contains a water soluble substance that suppresses bone loss in ovariectomized rats. Biosci Biotech Bio-chem. 2012; 76: 364-67.
Yarnel E, Abascal K. Multiphasic herbal prescribing for menstruating women. Alternat Complement Ther. 2009; 15: 126-34.
Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, McCaig CD, Penninger JM. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature 2006; 442: 457-60.
Zouari BK, Bardaa S, Khimiri M, Rebaii T, Tounsi S, Jlaiel L, Trigui M. Exploring the Urtica dioica leaves hemostatic and wound-healing potential. Biomed Res Int. 2017; 2017: 1-10.
