Chemical derivatization of pharmaceutical samples prior to Gas-Chromatography and Mass-Spectrometry analysis

Vivek K. Bajpai; Na Hyung Kim; Kangmin Kim

Chemical derivatization of pharmaceutical samples prior to Gas-Chromatography and Mass-Spectrometry analysis

Vivek K. Bajpai School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, South Korea.
Na Hyung Kim Department of Oriental Pharmacy, Wonkwang University, Iksan-City, Jeonbuk, South Korea.
Kangmin Kim Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, 79 Gobong-ro, Iksan-si-570-752, Joellabuk-do (Jeonbuk), South Korea.

Keywords: Chemical derivatization, Gas-Chromatography, Mass-Spectrometry, Pharmaceutical

DOI: 10.3329/bjp.v11i4.28588

References

Farag MA, Rasheed DM, Kamal IM. Volatiles and primary metabolites profiling in two Hibiscus sabdariffa (roselle) cultivars via headspace SPME-GC-MS and chemometrics. Food Res Int. 2015; 78: 327-35.

Japelt KB, Nielsen NJ, Wiese S, Christensen JH. Metabolic fingerprinting of Lactobacillus paracasei: A multi-criteria evaluation of methods for extraction of intracellular metabolites. Anal Bioanal Chem. 2015; 407: 6095-104.

Knapp DR. Handbook of analytical derivatization reaction. Vol. 10. New York, Wiley and Sons, 1979, p 10.

Kuhnel E, Laffan DDP, Lloyd-Jones GC, Martinez del Campo T, Shepperson IR, Slaughter JL. Mechanism of methyl esterification of carboxylic acids by trimethylsilyldiazomethane. Angewandte Chem Int. 2007; 46: 7075-78.